Levofloxacin origin and approved uses

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Levofloxacin is a generic name of the antibiotic agent which comes in the formulation of many branded medicines such as Levaquin, Leva-Pak, Tavanic, Levoday, Cravit and others. The medicine belongs to the 3rd generation class of fluoroquinolones and is approved for use by the FDA.

Actually the medicine was discovered by one of the Japanese pharmacological companies. The purpose of this antibiotic was to ensure the excellent antibacterial potency of the medicine and decrease the toxicity for the body.

Today Levofloxacin can be found in all the parts of the world and used for various infectious diseases.

U.S. FDA approved this medicine for a variety of infectious diseases in their acute state or chronically ongoing.

In the list of approval uses there are:

Acute bacterial sinusitis

Acute bacterial exacerbation of chronic bronchitis

Nosocomial pneumonia

Community-acquired pneumonia

Complicated skin and skin structure infections

Uncomplicated skin and skin structure infections (mild to moderate) including abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections

Chronic bacterial prostatitis

Complicated urinary tract infections (mild to moderate)

Acute pyelonephritis (mild to moderate)

Uncomplicated urinary tract infections

Inhalational anthrax

Off-label uses (not approved by the FDA) include:

Helicobacter Pylori eradication

Pelvic inflammatory disease (PID)

Gynecological infections

Enterocolitis (Shigella)

Epididymitis (non-gonococcal)

Legionnaires disease



Community-acquired pneumonia in children

Typhoid fever


Levofloxacin can be considered one of the well-known medicines with proven effectiveness. The long years of its use have shown its advantages and weak sides.

Advantages of the medicine include its convenient and easy use. The dose is taken only once a day which excludes the missing or skipping doses. This is of course one of the benefits for patients who often forget about taking several doses of the medicine per day.

The other advantage of the medicine is its high effectiveness against broad spectrum of susceptible bacteria. It is bactericidal for many existing types of bacteria with fast onset of action.

Patients using this antibiotic rarely complain about side effects of this medicine. It is safe and well-tolerated by most patients. In comparison with other medicines from the same drug class of fluoroquinolones, Levofloxacin does not impose the risks of any cardiovascular effects, central nervous system disturbances and phototoxicity.

As the medicine has no P-450 metabolism, it does not significantly interact with other medicines.

Levofloxacin shows greater gram-positive spectrum of activity against Streptococcus pneumoniae than other fluoroquinolones.

Excellent bioavailability both orally and intravenously makes Levofloxacin a drug of choice for many bacterial disorders demanding extra strength and extra amounts of the active components.

Main disadvantages of the medicine involve the risks of certain side effects particularly risk of peripheral neuropathy, prolongation of QT, risks of tendon ruptures.

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